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auto;vertical-align:middle;margin-right:5px}.tier-dot[data-tier=validated]{background:var(--tier-validated-dot)}.tier-dot[data-tier=measured]{background:var(--tier-measured-dot)}.tier-dot[data-tier=out-of-domain]{background:var(--tier-ood-dot)}.tier-dot[data-tier=predicted]{background:var(--tier-predicted-dot)}.tier-dot[data-tier=not-modellable]{background:var(--tier-nm-dot)}.bm-pbpk-drugtier{display:inline-flex;align-items:center;margin-top:6px}.pbpk-body-wrap{position:relative;max-width:420px;margin-inline:auto}.pbpk-body-svg{width:100%;height:340px;display:block}.pbpk-organ-label{font-family:var(--bm-font-sans, sans-serif);font-size:10px;font-weight:600;fill:var(--bm-text)}.pbpk-organ-kp{font-family:var(--bm-font-mono, ui-monospace, monospace);font-size:9.5px;fill:var(--bm-text-muted)}.pbpk-body-scale{display:flex;align-items:center;gap:8px;font-family:var(--bm-font-mono, ui-monospace, monospace);font-size:10px;color:var(--bm-text-subtle);margin-top:4px}.pbpk-body-scale-bar{flex:1;height:8px;border-radius:4px;background:linear-gradient(90deg,#eef1fa,#4f5bd5)}.pbpk-body-gated .pbpk-body-svg{opacity:.5;filter:saturate(.6)}.pbpk-body-gate-banner{position:absolute;inset:auto 8px 44px;background:var(--bm-bg);border:1px solid var(--tier-ood-bd);border-radius:var(--bm-radius-md, 12px);box-shadow:var(--bm-shadow-md, 0 6px 20px rgba(14,23,51,.08));padding:10px 12px;display:flex;gap:8px;align-items:flex-start;font-size:12px;line-height:1.5;color:var(--tier-ood-fg)}.pbpk-body-gate-banner>span:first-child{font-weight:700}.pbpk-body-fall{margin-top:10px}.pbpk-body-fall>summary{cursor:pointer;font-size:12px;color:var(--bm-accent);padding:4px 0}.bm-pbpk-drugpick{display:inline-flex;align-items:center;gap:10px;min-width:280px;height:40px;padding:0 10px 0 12px;border:1px solid #cfd0e0;border-radius:8px;background:#fff;cursor:pointer;font:inherit;text-align:left}.bm-pbpk-drugpick:hover{border-color:var(--bm-accent)}.bm-pbpk-drugpick:focus-visible{outline:2px solid var(--bm-accent);outline-offset:1px}.bm-pbpk-drugpick-name{font-size:15px;font-weight:600;color:var(--bm-text)}.bm-pbpk-drugpick-caret{margin-left:auto;color:var(--bm-text-subtle)}.pbpk-picker-overlay{position:fixed;inset:0;z-index:50;background:#0e173352;display:flex;align-items:flex-start;justify-content:center;padding:7vh 16px 16px}.pbpk-picker{width:100%;max-width:720px;max-height:82vh;display:flex;flex-direction:column;background:var(--bm-bg);border:1px solid var(--bm-border);border-radius:var(--bm-radius-lg, 18px);box-shadow:var(--bm-shadow-lg, 0 18px 48px rgba(14,23,51,.18));overflow:hidden}.pbpk-picker-head{padding:16px 18px;border-bottom:1px solid var(--bm-border)}.pbpk-picker-search{display:flex;align-items:center;gap:8px;height:44px;padding:0 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monospace);font-size:11px;opacity:.8}.pbpk-picker-list{overflow-y:auto}.pbpk-picker-group{padding:10px 18px 4px;background:var(--bm-bg-subtle);position:sticky;top:0}.pbpk-picker-row{display:flex;width:100%;align-items:center;gap:12px;padding:11px 18px;border:0;border-bottom:1px solid var(--bm-border);background:none;cursor:pointer;text-align:left;font:inherit}.pbpk-picker-row:hover{background:var(--bm-accent-subtle)}.pbpk-picker-row.is-current{background:var(--bm-accent-subtle);box-shadow:inset 3px 0 0 var(--bm-accent)}.pbpk-picker-row.is-disabled{cursor:not-allowed;opacity:.6}.pbpk-picker-row.is-disabled:hover{background:none}.pbpk-picker-name{display:block;font-size:15px;font-weight:600;color:var(--bm-text)}.pbpk-picker-row:hover .pbpk-picker-name{color:var(--bm-accent-ink)}.pbpk-picker-class{display:block;font-size:12px;color:var(--bm-text-subtle)}.pbpk-picker-meta{margin-left:auto;display:flex;align-items:center;gap:12px}.pbpk-picker-vss{font-family:var(--bm-font-mono, monospace);font-size:12px;color:var(--bm-text-muted);text-align:right;white-space:nowrap}.pbpk-picker-why{margin-left:auto;max-width:230px;font-size:11px;font-style:italic;color:var(--bm-text-subtle);text-align:right}.pbpk-picker-empty{padding:28px 18px;text-align:center;color:var(--bm-text-subtle);font-size:14px}.bm-pbpk-tile-ood{box-shadow:inset 0 0 0 1.5px var(--tier-ood-bd)}.bm-pbpk-tile-ood .bm-pbpk-tsub{color:var(--tier-ood-fg)}.bm-pbpk-tile-ood .bm-pbpk-tsub s{color:var(--bm-text-subtle)}.bm-pbpk-ood-cell{color:var(--tier-ood-fg);font-weight:600;white-space:nowrap}.bm-pbpk-cmp .tier-badge{vertical-align:middle;margin-left:5px}.v2-page{max-width:1480px;margin-inline:auto;width:100%;padding:8px 24px 56px}.v2-hero{display:grid;grid-template-columns:minmax(320px,.82fr) minmax(0,1.6fr);gap:16px;align-items:start;margin:14px 0 16px}.v2-left,.v2-right{display:flex;flex-direction:column;gap:14px;min-width:0}.v2-tiles{display:grid;grid-template-columns:1fr 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monospace);font-size:12px;color:var(--bm-accent-ink);font-weight:600;background:var(--bm-accent-subtle);padding:2px 9px;border-radius:var(--bm-radius-pill, 999px)}.v2-body-main{padding:8px 14px 4px}.v2-scrubber{display:flex;align-items:center;gap:12px;padding:8px 16px 14px}.v2-play{width:36px;height:36px;flex:0 0 auto;border-radius:50%;background:var(--bm-accent);color:var(--bm-accent-fg);display:inline-flex;align-items:center;justify-content:center;font-size:12px;box-shadow:var(--bm-shadow-sm)}.v2-play:hover{background:var(--bm-accent-hover, #3e49c2)}.v2-scrub-input{flex:1;appearance:none;-webkit-appearance:none;height:6px;border-radius:3px;background:var(--bm-bg-panel);cursor:pointer}.v2-scrub-input::-webkit-slider-thumb{-webkit-appearance:none;width:16px;height:16px;border-radius:50%;background:var(--bm-bg);border:3px solid var(--bm-accent);box-shadow:var(--bm-shadow-sm);cursor:grab}.v2-scrub-input::-moz-range-thumb{width:16px;height:16px;border-radius:50%;background:var(--bm-bg);border:3px solid var(--bm-accent);cursor:grab}.v2-scrub-input:focus-visible{outline:2px solid var(--bm-accent);outline-offset:3px}.v2-scrub-meta{font-family:var(--bm-font-mono, monospace);font-size:11px;color:var(--bm-text-subtle);min-width:76px;text-align:right}.bm-sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.v2-plot-canvas-wrap{position:relative}.v2-crosshair-readout{position:absolute;top:8px;right:12px;background:var(--bm-bg);border:1px solid var(--bm-border);border-radius:var(--bm-radius-md, 12px);box-shadow:var(--bm-shadow-md, 0 6px 20px rgba(14,23,51,.08));padding:8px 12px;font-family:var(--bm-font-mono, monospace);font-size:12px;pointer-events:none;min-width:132px}.v2-crosshair-readout .row{display:flex;justify-content:space-between;gap:12px}.v2-crosshair-readout .t{color:var(--bm-text-muted)}.v2-crosshair-readout .c{color:var(--bm-accent-ink);font-weight:600}.v2-pin-flag{fill:var(--bm-bg);stroke:var(--bm-accent);stroke-width:1.5}.v2-pin-flag-active{fill:var(--bm-accent)}.v2-pin-label{font-family:var(--bm-font-mono, monospace);font-size:10px;font-weight:600}.v2-pinbar{display:flex;flex-wrap:wrap;gap:8px;padding:4px 4px 8px;align-items:center}.v2-pinbar-label{font-family:var(--bm-font-mono, monospace);font-size:10px;text-transform:uppercase;letter-spacing:.5px;color:var(--bm-text-subtle)}.v2-pinchip{display:inline-flex;align-items:center;gap:7px;height:28px;padding:0 6px 0 11px;border-radius:var(--bm-radius-pill, 999px);background:var(--bm-bg-subtle);box-shadow:inset 0 0 0 1px var(--bm-border);font-family:var(--bm-font-mono, monospace);font-size:12px;color:var(--bm-text);cursor:pointer}.v2-pinchip.is-driving{background:var(--bm-accent-subtle);box-shadow:inset 0 0 0 1px var(--bm-accent);color:var(--bm-accent-ink);font-weight:600}.v2-pinchip:focus-visible{outline:2px solid var(--bm-accent);outline-offset:2px}.v2-pinchip-drive{font-size:9px;letter-spacing:.4px;text-transform:uppercase;opacity:.85}.v2-pinchip-x{width:16px;height:16px;border-radius:50%;display:inline-flex;align-items:center;justify-content:center;color:var(--bm-text-subtle)}.v2-pinchip-x:hover{background:var(--bm-border);color:var(--bm-text)}.bm-pbpk-datatable{margin:2px 4px 6px}.bm-pbpk-datatable>summary{cursor:pointer;font-size:12px;color:var(--bm-accent);padding:4px 0}.bm-pbpk-datatable-scroll{max-height:220px;overflow:auto;margin-top:6px}.bm-pbpk-datatable table{border-collapse:collapse;font-family:var(--bm-font-mono, monospace);font-size:11px;width:100%}.bm-pbpk-datatable th,.bm-pbpk-datatable td{border:1px solid var(--bm-border);padding:3px 8px;text-align:right;white-space:nowrap}.bm-pbpk-datatable thead th{background:var(--bm-bg-subtle);position:sticky;top:0}.bm-pbpk-datatable tbody th{font-weight:600;color:var(--bm-text-muted)}.bm-pbpk-btn-file{cursor:pointer}.bm-pbpk-computing{margin:2px 0 10px;padding:10px 14px;background:var(--bm-accent-subtle, #eef0fb);border-radius:10px;font-size:13px;color:var(--bm-accent-ink, #3a45b0)}.bm-pbpk-spin{display:inline-block;width:12px;height:12px;border:2px solid var(--bm-border-strong, #ccd3e4);border-top-color:var(--bm-accent, #4f5bd5);border-radius:50%;vertical-align:-1px;animation:bm-pbpk-spin .7s linear infinite}@keyframes bm-pbpk-spin{to{transform:rotate(360deg)}}